Blender
Open preferences
In Blender, Cmd + Comma will open preferences. It is listed for the Mac.
Where it works: Anywhere
The manual names this as a Mac key. Other Mac keys are not listed there, so they are not shown here.
Where this comes from
Default Keymap - Blender 2.80 Manual
Documentation checked on 2026-09-14. That is a documentation review, not a test run inside the application.